Technology That Reactivates Cells, Tissues And Organs One Hour After Death – Nation World News

Health

The results of an impressive experiment promise to open up a new avenue in emergency medicine, but will undoubtedly cause anxiety and skepticism among some, for whom the tested new technology makes them “re-animator” like much of science fiction and horror movies. can remind. 1985) and “Are we dead… or what?” (1988), among other films and literary works.

Within minutes of the heart stopping, a cascade of biochemical events triggered by a lack of blood flow, oxygen, and nutrients begins to destroy the body’s cells and organs. But some scientists, thanks to a new technology they created that supply fluids specifically designed to protect the cells of organs and tissues, increase blood circulation and other cellular functions an hour after pigs die. Have managed to restore functions.

This fascinating experiment concludes a study that constitutes another step in a line of research and development initiated as a result of a study published in 2019 in which scientists at Yale University in the United States investigated circulation in the brain of a dead pig. and restored some cellular functions. Using a technique he named BrainX.

“If we were able to restore certain cellular functions after death in the brain, an organ known to be susceptible to ischemia (inadequate blood supply), we hypothesized that something similar could be achieved in other organs as well. Is.” transplantable vital cells”, explains Nenad Seston, co-author of that study and also of the new.

In the new study, Seston, David Andrijevic, Zvonimir Verselja and others applied a modified version of BrainX called OrganX to a whole pig. The technology consists of a perfusion device (similar to machines used to work out the heart and lungs during some surgeries) and an experimental fluid containing compounds capable of promoting cellular health and suppressing inflammation throughout the body.

Even six hours after the OrganEx treatment, the scientists found that key cellular functions in several areas of the pigs’ bodies (including the heart, liver, and kidneys) were activated and that some organ function was restored. For example, they found evidence of electrical activity in the heart, which retained its ability to contract.

The artist’s impression of cells was reactivated an hour after the heart stopped and died. (Illustration: Amazing/NCYT)

Normally, when the heart stops beating, organs begin to swell, blood vessels collapse and circulation is blocked. However, circulation was restored and organs from dead pigs that had received OrganEx treatment appeared functional at the cell and tissue level.

“Under the microscope, it was difficult to tell the difference between a healthy organ and an organ treated with OrganEx technology after death,” Vercellza says.

Like in the 2019 experiment, the researchers also found that cellular activity was restored in some areas of the brain, although no organized electrical activity indicating consciousness was detected.

The team was particularly surprised to see spontaneous and involuntary muscle movements in the head and neck regions when they tested the treated animals. These movements indicate the preservation of certain motor functions, as Seston explains.

The first and most obvious application of OrganEx technology may be to expand the availability of donor organs for transplantation. But it can also be used to prolong the life of organs in human patients and may even be used as a treatment for organs or tissues damaged by ischemia during a heart attack or stroke. Is.

Seston and his colleagues present technical details of their latest experiment in the academic journal Nature, under the title “Cellular recovery after prolonged warm ischemia of the whole body.” (Font: NCYT D Amazing,

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